Venosane Travelline Graduation Compression Socks, Knee-Length are designed especially for travel. Encourage ciruclation to help legs feel energized during long periods of immobility such as traveling by air or during long car rides, which can lead to blood clots and Deep Vein Thrombosis (DVT). NOt made with natural rubber latex. 15-20 mmHg. WOmen's 85% nylong/15% spandex. Mens 90% nylon/10% Spandex. Sizing: Measure fullest part of calf and smalles part of the ankle above the ankle bone. Medium: Women's, calf 11-1/2" to 15-1/2", ankle 8" to 9-1/2"; Men's, calf 13" to 17", ankle 8-1/2" to 9-1/2"